Ontology highlight
ABSTRACT:
SUBMITTER: Cho KW
PROVIDER: S-EPMC4252867 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cho Kae Won KW Morris David L DL DelProposto Jennifer L JL Geletka Lynn L Zamarron Brian B Martinez-Santibanez Gabriel G Meyer Kevin A KA Singer Kanakadurga K O'Rourke Robert W RW Lumeng Carey N CN
Cell reports 20141009 2
An adaptive immune response triggered by obesity is characterized by the activation of adipose tissue CD4(+) T cells by unclear mechanisms. We have examined whether interactions between adipose tissue macrophages (ATMs) and CD4(+) T cells contribute to adipose tissue metainflammation. Intravital microscopy identifies dynamic antigen-dependent interactions between ATMs and T cells in visceral fat. Mice deficient in major histocompatibility complex class II (MHC II) showed protection from diet-ind ...[more]