Ontology highlight
ABSTRACT:
SUBMITTER: Lee BC
PROVIDER: S-EPMC4833527 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lee Byung-Cheol BC Kim Myung-Sunny MS Pae Munkyong M Yamamoto Yasuhiko Y Eberlé Delphine D Shimada Takeshi T Kamei Nozomu N Park Hee-Sook HS Sasorith Souphatta S Woo Ju Rang JR You Jia J Mosher William W Brady Hugh J M HJ Shoelson Steven E SE Lee Jongsoon J
Cell metabolism 20160331 4
Obesity-induced inflammation mediated by immune cells in adipose tissue appears to participate in the pathogenesis of insulin resistance. We show that natural killer (NK) cells in adipose tissue play an important role. High-fat diet (HFD) increases NK cell numbers and the production of proinflammatory cytokines, notably TNFα, in epididymal, but not subcutaneous, fat depots. When NK cells were depleted either with neutralizing antibodies or genetic ablation in E4bp4(+/-) mice, obesity-induced ins ...[more]