Ontology highlight
ABSTRACT:
SUBMITTER: Logue MW
PROVIDER: S-EPMC4253055 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20140827 6
<h4>Background</h4>Less is known about the genetic basis of Alzheimer's disease (AD) in African Americans (AAs) than in non-Hispanic whites.<h4>Methods</h4>Whole exome sequencing (WES) was performed on seven AA AD cases. Disease association with potentially AD-related variants from WES was assessed in an AA discovery cohort of 422 cases and 394 controls. Replication was sought in an AA sample of 1037 cases and 1869 controls from the Alzheimer Disease Genetics Consortium (ADGC).<h4>Results</h4>Fo ...[more]