Ontology highlight
ABSTRACT:
SUBMITTER: Mez J
PROVIDER: S-EPMC5318231 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20161020 2
<h4>Introduction</h4>African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.<h4>Methods</h4>We conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, ...[more]