A novel tumor suppressor function of Kindlin-3 in solid cancer.
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ABSTRACT:
SUBMITTER: Djaafri I
PROVIDER: S-EPMC4253411 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Djaafri Ibtissem I Khayati Farah F Menashi Suzanne S Tost Jorg J Podgorniak Marie-Pierre MP Sadoux Aurelie A Daunay Antoine A Teixeira Luis L Soulier Jean J Idbaih Ahmed A Setterblad Niclas N Fauvel Françoise F Calvo Fabien F Janin Anne A Lebbé Celeste C Mourah Samia S
Oncotarget 20141001 19
Kindlin-3 (FERMT-3) is known to be central in hemostasis and thrombosis control and its deficiency disrupts platelet aggregation and causes Leukocyte Adhesion Deficiency disease. Here we report that Kindlin-3 has a tumor suppressive role in solid cancer. Our present genetic and functional data show that Kindlin-3 is downregulated in several solid tumors by a mechanism involving gene hypermethylation and deletions. In vivo experiments demonstrated that Kindlin-3 knockdown in 2 tumor cell models ( ...[more]
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