Ontology highlight
ABSTRACT:
SUBMITTER: Strochlic TI
PROVIDER: S-EPMC4253492 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Strochlic Todd I TI Stavrides Kevin P KP Thomas Sam V SV Nicolas Emmanuelle E O'Reilly Alana M AM Peterson Jeffrey R JR
EMBO reports 20140915 11
The enzyme CTP synthase (CTPS) dynamically assembles into macromolecular filaments in bacteria, yeast, Drosophila, and mammalian cells, but the role of this morphological reorganization in regulating CTPS activity is controversial. During Drosophila oogenesis, CTPS filaments are transiently apparent in ovarian germline cells during a period of intense genomic endoreplication and stockpiling of ribosomal RNA. Here, we demonstrate that CTPS filaments are catalytically active and that their assembl ...[more]