Ontology highlight
ABSTRACT:
SUBMITTER: Aughey GN
PROVIDER: S-EPMC4759343 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Aughey Gabriel N GN Grice Stuart J SJ Liu Ji-Long JL
PLoS genetics 20160218 2
CTP synthase (CTPsyn) is essential for the biosynthesis of pyrimidine nucleotides. It has been shown that CTPsyn is incorporated into a novel cytoplasmic structure which has been termed the cytoophidium. Here, we report that Myc regulates cytoophidium formation during Drosophila oogenesis. We have found that Myc protein levels correlate with cytoophidium abundance in follicle epithelia. Reducing Myc levels results in cytoophidium loss and small nuclear size in follicle cells, while overexpressio ...[more]