Ontology highlight
ABSTRACT:
SUBMITTER: Rayahin JE
PROVIDER: S-EPMC4253680 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Rayahin Jamie E JE Buhrman Jason S JS Gemeinhart Richard A RA
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20140921
Although potent, proteins often require chemical modification for therapeutic use. Immunogenicity, difficult synthesis, and scale-up of these modifications are all engineering obstacles that stand in the way of expanding the use of these therapeutics. Melittin, a peptide derived from bee venom, has been shown to modulate inflammation. Although potentially therapeutic, the native peptide causes cell lysis and toxicity significantly hindering therapeutic application. Based upon the knowledge of th ...[more]