Ontology highlight
ABSTRACT:
SUBMITTER: Shu C
PROVIDER: S-EPMC4254336 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Shu Chang C Li Xin X Li Pingwei P
Cytokine & growth factor reviews 20140622 6
Microbial nucleic acids induce potent innate immune responses by stimulating the expression of type I interferons. Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyze the synthesis of a cyclic dinucleotide cGAMP with 2',5' and 3',5'phosphodiester linkages. cGAMP binds to the adaptor STING located on the endoplasmic reticulum membrane and mediates the recruitment and activation of the protein kinase TBK ...[more]