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Chicken DNA Sensing cGAS-STING Signal Pathway Mediates Broad Spectrum Antiviral Functions.

ABSTRACT: The innate DNA sensing receptors are one family of pattern recognition receptors and play important roles in antiviral infections, especially DNA viral infections. Among the multiple DNA sensors, cGAS has been studied intensively and is most defined in mammals. However, DNA sensors in chickens have not been much studied, and the chicken cGAS is still not fully understood. In this study, we investigated the chicken cGAS-STING signal axis, revealed its synergistic activity, species-specificity, and the signal essential sites in cGAS. Importantly, both cGAS and STING exhibited antiviral effects against DNA viruses, retroviruses, and RNA viruses, suggesting the broad range antiviral functions and the critical roles in chicken innate immunity.

SUBMITTER: Li S

PROVIDER: S-EPMC7563795 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Chicken DNA Sensing cGAS-STING Signal Pathway Mediates Broad Spectrum Antiviral Functions.

Li Shuangjie S Yang Jie J Zhu Yuanyuan Y Ji Xingyu X Wang Kun K Jiang Sen S Luo Jia J Wang Hui H Zheng Wanglong W Chen Nanhua N Ye Jianqiang J Meurens François F Zhu Jianzhong J

Vaccines 20200709 3

The innate DNA sensing receptors are one family of pattern recognition receptors and play important roles in antiviral infections, especially DNA viral infections. Among the multiple DNA sensors, cGAS has been studied intensively and is most defined in mammals. However, DNA sensors in chickens have not been much studied, and the chicken cGAS is still not fully understood. In this study, we investigated the chicken cGAS-STING signal axis, revealed its synergistic activity, species-specificity, an ...[more]

PMID: 32660114

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