Unknown

Dataset Information

0

Pre-diagnostic serum levels of inflammation markers and risk of ovarian cancer in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial.


ABSTRACT: OBJECTIVE:Pro-inflammatory mechanisms may explain the increased ovarian cancer risk linked to more lifetime ovulations, endometriosis, and exposure to talc and asbestos, as well as decreased risk with non-steroidal anti-inflammatory drugs. Limited data are available to estimate ovarian cancer risk associated with levels of circulating inflammatory markers. METHODS:We conducted a nested case-control study within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Pre-diagnostic serum levels of 46 inflammation-related biomarkers (11 with a priori hypotheses; 35 agnostic) were measured in 149 incident ovarian cancer cases and 149 matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression and adjusted for identified covariates. RESULTS:Increased ovarian cancer risk was associated with elevated levels of C-reactive protein (CRP) [tertile (T)3 vs. T1: OR (95% CI) 2.04 (1.06-3.93), p-trend=0.03], interleukin (IL)-1? [detectable vs. undetectable: 2.23 (1.14-4.34)] and tumor necrosis factor alpha (TNF-?) [T3 vs. T1: 2.21 (1.06-4.63), p-trend=0.04]. Elevated IL-8 was non-significantly associated with risk [T3 vs. T1: 1.86 (0.96-3.61), p-trend=0.05]. In analyses restricted to serous ovarian cancer (n=83), the associations with CRP and IL-8 remained or strengthened [CRP T3 vs. T1: 3.96 (1.14-11.14), p-trend=0.008; IL-8 T3 vs. T1: 3.05 (1.09-8.51), p-trend=0.03]. Elevated levels of CRP and TNF-? remained positively associated with ovarian cancer risk in analysis restricted to specimens collected at least 5years before diagnosis (n=56). CONCLUSION:These results suggest that CRP, IL-1?, IL-8, and TNF-? are associated with increased risk of subsequently developing ovarian cancer.

SUBMITTER: Trabert B 

PROVIDER: S-EPMC4254357 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pre-diagnostic serum levels of inflammation markers and risk of ovarian cancer in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial.

Trabert Britton B   Pinto Ligia L   Hartge Patricia P   Kemp Troy T   Black Amanda A   Sherman Mark E ME   Brinton Louise A LA   Pfeiffer Ruth M RM   Shiels Meredith S MS   Chaturvedi Anil K AK   Hildesheim Allan A   Wentzensen Nicolas N  

Gynecologic oncology 20140823 2


<h4>Objective</h4>Pro-inflammatory mechanisms may explain the increased ovarian cancer risk linked to more lifetime ovulations, endometriosis, and exposure to talc and asbestos, as well as decreased risk with non-steroidal anti-inflammatory drugs. Limited data are available to estimate ovarian cancer risk associated with levels of circulating inflammatory markers.<h4>Methods</h4>We conducted a nested case-control study within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Pre  ...[more]

Similar Datasets

| S-EPMC5159268 | biostudies-literature
| S-EPMC3582194 | biostudies-literature
| S-EPMC3818308 | biostudies-literature
| S-EPMC2873186 | biostudies-literature
| S-EPMC3010173 | biostudies-literature
| S-EPMC8169811 | biostudies-literature
| S-EPMC6521920 | biostudies-literature
| S-EPMC4852935 | biostudies-literature
| S-EPMC3584637 | biostudies-literature
| S-EPMC7298621 | biostudies-literature