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Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial.

ABSTRACT: Inflammation is proposed to increase risk of developing endometrial cancer, but few prospective epidemiologic studies have investigated the relationship between circulating inflammation markers and endometrial cancer risk. In a nested case-control study within the PLCO Screening Trial we measured serum levels of 64 inflammation-related biomarkers in 284 incident endometrial cancer cases and 284 matched controls. Using multivariable logistic regression inflammation markers were evaluated individually and combined into a cross-validated inflammation score. Of 64 markers, 22 were associated with endometrial cancer risk at p?

SUBMITTER: Trabert B 

PROVIDER: S-EPMC5159268 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial.

Trabert Britton B   Eldridge Ronald C RC   Pfeiffer Ruth M RM   Shiels Meredith S MS   Kemp Troy J TJ   Guillemette Chantal C   Hartge Patricia P   Sherman Mark E ME   Brinton Louise A LA   Black Amanda A   Chaturvedi Anil K AK   Hildesheim Allan A   Berndt Sonja I SI   Safaeian Mahboobeh M   Pinto Ligia L   Wentzensen Nicolas N  

International journal of cancer 20161107 3

Inflammation is proposed to increase risk of developing endometrial cancer, but few prospective epidemiologic studies have investigated the relationship between circulating inflammation markers and endometrial cancer risk. In a nested case-control study within the PLCO Screening Trial we measured serum levels of 64 inflammation-related biomarkers in 284 incident endometrial cancer cases and 284 matched controls. Using multivariable logistic regression inflammation markers were evaluated individu  ...[more]

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