Ontology highlight
ABSTRACT:
SUBMITTER: Flak JN
PROVIDER: S-EPMC4255234 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Flak Jonathan N JN Patterson Christa M CM Garfield Alastair S AS D'Agostino Giuseppe G Goforth Paulette B PB Sutton Amy K AK Malec Paige A PA Wong Jenny-Marie T JT Germani Mark M Jones Justin C JC Rajala Michael M Satin Leslie L Rhodes Christopher J CJ Olson David P DP Kennedy Robert T RT Heisler Lora K LK Myers Martin G MG
Nature neuroscience 20141110 12
Hypoglycemia initiates the counter-regulatory response (CRR), in which the sympathetic nervous system, glucagon and glucocorticoids restore glucose to appropriate concentrations. During starvation, low leptin levels restrain energy utilization, enhancing long-term survival. To ensure short-term survival during hypoglycemia in fasted animals, the CRR must overcome this energy-sparing program and nutrient depletion. Here we identify in mice a previously unrecognized role for leptin and a populatio ...[more]