Ontology highlight
ABSTRACT:
SUBMITTER: Mastro TL
PROVIDER: S-EPMC4256765 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Mastro Tara L TL Forsburg Susan L SL
Genetics 20141006 4
Schizosaccharomyces pombe Rad16 is the ortholog of the XPF structure-specific endonuclease, which is required for nucleotide excision repair and implicated in the single strand annealing mechanism of recombination. We show that Rad16 is important for proper completion of meiosis. In its absence, cells suffer reduced spore viability and abnormal chromosome segregation with evidence for fragmentation. Recombination between homologous chromosomes is increased, while recombination within sister chro ...[more]