Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC4257720 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Zhao Chunhua C Qi Jianzhao J Tao Weixing W He Lei L Xu Wei W Chan Jason J Deng Zixin Z
PloS one 20141205 12
Ascamycin (ACM) and dealanylascamycin (DACM) are nucleoside antibiotics elaborated by Streptomyces sp. JCM9888. The later shows broad spectrum inhibition activity to various gram-positive and gram-negative bacteria, eukaryotic Trypanosoma and is also toxic to mice, while ascamycin is active against very limited microorganisms, such as Xanthomonas. Both compounds share an unusual 5'-O-sulfonamide moiety which is attached to an adenosine nucleoside. In this paper, we first report on the 30 kb gene ...[more]