Ontology highlight
ABSTRACT:
SUBMITTER: Yin M
PROVIDER: S-EPMC4051428 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Yin Min M Yan Yijun Y Lohman Jeremy R JR Huang Sheng-Xiong SX Ma Ming M Zhao Guang-Rong GR Xu Li-Hua LH Xiang Wensheng W Shen Ben B
Organic letters 20140509 11
Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of 1 features an acyltransferase-less type I polyketide synthase to construct its carbon backbone but may proceed via 2 as a key intermediate, invoking a provocative reduction of a phenol to a cyclohexanone moiety in nat ...[more]