Targeting ?4?7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
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ABSTRACT:
SUBMITTER: Byrareddy SN
PROVIDER: S-EPMC4257865 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
Byrareddy Siddappa N SN Kallam Brianne B Arthos James J Cicala Claudia C Nawaz Fatima F Hiatt Joseph J Kersh Ellen N EN McNicholl Janet M JM Hanson Debra D Reimann Keith A KA Brameier Markus M Walter Lutz L Rogers Kenneth K Mayne Ann E AE Dunbar Paul P Villinger Tara T Little Dawn D Parslow Tristram G TG Santangelo Philip J PJ Villinger Francois F Fauci Anthony S AS Ansari Aftab A AA
Nature medicine 20141124 12
α4β7 integrin-expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α4β7 monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIVmac251. In treated animals that became infected, the GALT was significantly protected from infecti ...[more]
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