Ontology highlight
ABSTRACT:
SUBMITTER: Sun H
PROVIDER: S-EPMC5881498 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sun Hao H Lagarrigue Frederic F Gingras Alexandre R AR Fan Zhichao Z Ley Klaus K Ginsberg Mark H MH
The Journal of cell biology 20180313 4
Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many pathological processes. A proline mutation in the central integrin β3 transmembrane domain (TMD) creates a flexible kink that uncouples the topology of the inner half of the TMD from the outer half. In this study, using leukocyte integrin α4β7, which enables development of gut-associated lymphoid tissue (GALT), we examined the biological effe ...[more]