Ontology highlight
ABSTRACT:
SUBMITTER: Schiwon M
PROVIDER: S-EPMC4258064 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Schiwon Marzena M Weisheit Christina C Franken Lars L Gutweiler Sebastian S Dixit Akanksha A Meyer-Schwesinger Catherine C Pohl Judith-Mira JM Maurice Nicholas J NJ Thiebes Stephanie S Lorenz Kristina K Quast Thomas T Fuhrmann Martin M Baumgarten Georg G Lohse Martin J MJ Opdenakker Ghislain G Bernhagen Jürgen J Bucala Rick R Panzer Ulf U Kolanus Waldemar W Gröne Hermann-Josef HJ Garbi Natalio N Kastenmüller Wolfgang W Knolle Percy A PA Kurts Christian C Engel Daniel R DR
Cell 20140101 3
The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-) macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C(+) macrophages. Such Ly6C(+) macrophages played a previously undescribed helper role: once recruited ...[more]