Ontology highlight
ABSTRACT:
SUBMITTER: Frentsch M
PROVIDER: S-EPMC4548794 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Frentsch Marco M Stark Regina R Matzmohr Nadine N Meier Sarah S Durlanik Sibel S Schulz Axel R AR Stervbo Ulrik U Jürchott Karsten K Gebhardt Friedemann F Heine Guido G Reuter Morgan A MA Betts Michael R MR Busch Dirk D Thiel Andreas A
Blood 20130529 3
CD8(+) T cells play an essential role in immunity against intracellular pathogens, with cytotoxicity being considered their major effector mechanism. However, we here demonstrate that a major part of central and effector memory CD8(+) T cells expresses CD40L, one key molecule for CD4(+) T-cell-mediated help. CD40L(+) CD8(+) T cells are detectable among human antigen-specific immune responses, including pathogens such as influenza and yellow fever virus. CD40L(+) CD8(+) T cells display potent hel ...[more]