Ontology highlight
ABSTRACT:
SUBMITTER: Ilieva KM
PROVIDER: S-EPMC4258403 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Molecular cancer therapeutics 20141110 12
Malignant melanoma is associated with poor clinical prognosis; however, novel molecular and immune therapies are now improving patient outcomes. Almost 50% of melanomas harbor targetable activating mutations of BRAF that promote RAS-RAF-MEK-ERK pathway activation and melanoma proliferation. Recent evidence also indicates that melanomas bearing mutant BRAF may also have altered immune responses, suggesting additional avenues for treatment of this patient group. The small molecule inhibitors selec ...[more]