MEK inhibition and immune responses in advanced melanoma.
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ABSTRACT:
SUBMITTER: Dummer R
PROVIDER: S-EPMC5593717 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
MEK inhibition and immune responses in advanced melanoma.
Dummer Reinhard R Ramelyte Egle E Schindler Sabrina S Thürigen Olaf O Levesque Mitchell P MP Koelblinger Peter P
Oncoimmunology 20170810 8
phase II and III clinical trials demonstrated modest anti- tumor activity of Binimetinib (MEK162) - a potent allosteric inhibitor of MEK1 and MEK2- in patients with advanced NRAS mutant melanoma. The analysis of the NEMO study in NRAS mutated melanoma, has shown that pre-treatment with immunotherapy improved the outcome of binimetinib therapy. We discuss this finding in the context of <i>in vitro</i> and <i>in vivo</i> effects of MEK inhibition on immuno-critical pathways and interactions. ...[more]
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