Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimaru T
PROVIDER: S-EPMC4258681 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20141208
Xanthohumol (XN) is a natural anticancer compound that inhibits the proliferation of oestrogen receptor-α (ERα)-positive breast cancer cells. However, the precise mechanism of the antitumour effects of XN on oestrogen (E2)-dependent cell growth, and especially its direct target molecule(s), remain(s) largely unknown. Here, we focus on whether XN directly binds to the tumour suppressor protein prohibitin 2 (PHB2), forming a novel natural antitumour compound targeting the BIG3-PHB2 complex and act ...[more]