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Design strategies for bioorthogonal smart probes.

ABSTRACT: Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or therapeutic agents upon reaction, allow for the visualization of biomolecules or targeted delivery even in the presence of excess unreacted probe. This review discusses the strategies used in the development of bioorthogonal smart probes and highlights the potential of these probes to further our understanding of biology.

SUBMITTER: Shieh P 

PROVIDER: S-EPMC4259128 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Design strategies for bioorthogonal smart probes.

Shieh Peyton P   Bertozzi Carolyn R CR  

Organic & biomolecular chemistry 20141015 46

Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or therapeutic agents upon reaction, allow for the visualization of biomolecules or targeted delivery even in the presence of excess unreacted probe. This review discusses the strategies used in the development of bioorthogonal smart probes and highlights the potential of these probes to further our understanding of bi  ...[more]

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