Ontology highlight
ABSTRACT:
SUBMITTER: Chinthalapudi K
PROVIDER: S-EPMC4259812 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Chinthalapudi Krishna K Rangarajan Erumbi S ES Patil Dipak N DN George Eric M EM Brown David T DT Izard Tina T
The Journal of cell biology 20141201 5
Adherens junctions (AJs) and focal adhesion (FA) complexes are necessary for cell migration and morphogenesis, and for the development, growth, and survival of all metazoans. Vinculin is an essential regulator of both AJs and FAs, where it provides links to the actin cytoskeleton. Phosphatidylinositol 4,5-bisphosphate (PIP2) affects the functions of many targets, including vinculin. Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vin ...[more]