Dataset Information

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

ABSTRACT: Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on adaptive immunity. Loss of TLR5 has profound effects on the microbiota that include greater temporal instability of major lineages and upregulation of flagellar motility genes that may be linked to the reduced levels of anti-flagellin antibodies in the TLR5(-/-) host. A variety of human TLR5 gene alleles exist that also associated with inflammatory conditions and may do so via effects on the gut microbiome and altered host-microbial crosstalk.

SUBMITTER: Leifer CA

PROVIDER: S-EPMC4259828 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

Leifer Cynthia A CA McConkey Cameron C Li Sha S Chassaing Benoit B Gewirtz Andrew T AT Ley Ruth E RE

Immunology letters 20141002 2 Pt A

Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on adaptive immunity. Loss of TLR5 has profound effects on the microbiota that include greater temporal instability of major lineages and upregulation of flagellar motility genes that m ...[more]

PMID: 25284610

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Dataset Information

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

Publications

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

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