Ontology highlight
ABSTRACT:
SUBMITTER: Watza D
PROVIDER: S-EPMC7211135 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Watza Donovan D Lusk Christine M CM Dyson Gregory G Purrington Kristen S KS Wenzlaff Angela S AS Neslund-Dudas Christine C Soubani Ayman O AO Gadgeel Shirish M SM Schwartz Ann G AG
International journal of cancer 20191212 3
Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucleotide polymorphisms (SNPs) proximal to 2,069 genes within 48 immune pathways. We modeled the contribution of these variants to lung cancer risk in a discovery sample of 1,932 lung c ...[more]