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Adeno-associated virus-mediated cancer gene therapy: current status.

ABSTRACT: Gene therapy is one of the frontiers of modern medicine. Adeno-associated virus (AAV)-mediated gene therapy is becoming a promising approach to treat a variety of diseases and cancers. AAV-mediated cancer gene therapies have rapidly advanced due to their superiority to other gene-carrying vectors, such as the lack of pathogenicity, the ability to transfect both dividing and non-dividing cells, low host immune response, and long-term expression. This article reviews and provides up to date knowledge on AAV-mediated cancer gene therapy.

SUBMITTER: Luo J

PROVIDER: S-EPMC4259838 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Adeno-associated virus-mediated cancer gene therapy: current status.

Luo Jingfeng J Luo Yuxuan Y Sun Jihong J Zhou Yurong Y Zhang Yajing Y Yang Xiaoming X

Cancer letters 20141110 2 Pt B

Gene therapy is one of the frontiers of modern medicine. Adeno-associated virus (AAV)-mediated gene therapy is becoming a promising approach to treat a variety of diseases and cancers. AAV-mediated cancer gene therapies have rapidly advanced due to their superiority to other gene-carrying vectors, such as the lack of pathogenicity, the ability to transfect both dividing and non-dividing cells, low host immune response, and long-term expression. This article reviews and provides up to date knowle ...[more]

PMID: 25444906

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