Physiologically based pharmacokinetic modeling and simulation in pediatric drug development.

ABSTRACT: Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age-specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique.

SUBMITTER: Maharaj AR 

PROVIDER: S-EPMC4260000 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature