Integrin ?v in the mechanical response of osteoblast lineage cells.
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ABSTRACT:
SUBMITTER: Kaneko K
PROVIDER: S-EPMC4260650 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Integrin αv in the mechanical response of osteoblast lineage cells.
Kaneko Keiko K Ito Masako M Naoe Yoshinori Y Lacy-Hulbert Adam A Ikeda Kyoji K
Biochemical and biophysical research communications 20140413 2
Although osteoblast lineage cells, especially osteocytes, are thought to be a primary mechanosensory cell in bone, the identity of the mechano-receptor and downstream mechano-signaling pathways remain largely unknown. Here we show using osteoblastic cell model of mechanical stimulation with fluid shear stress that in the absence of integrin αv, phosphorylation of the Src substrate p130Cas and JNK was impaired, culminating in an inhibition of nuclear translocation of YAP/TAZ and subsequent transc ...[more]
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