Ontology highlight
ABSTRACT:
SUBMITTER: Overstreet MG
PROVIDER: S-EPMC4159184 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Nature immunology 20130811 9
Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition ...[more]