Ontology highlight
ABSTRACT:
SUBMITTER: Wagenaar TR
PROVIDER: S-EPMC4260813 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Pigment cell & melanoma research 20131015 1
Resistance to the BRAF inhibitor vemurafenib poses a significant problem for the treatment of BRAFV600E-positive melanomas. It is therefore critical to prospectively identify all vemurafenib resistance mechanisms prior to their emergence in the clinic. The vemurafenib resistance mechanisms described to date do not result from secondary mutations within BRAFV600E. To search for possible mutations within BRAFV600E that can confer drug resistance, we developed a systematic experimental approach inv ...[more]