Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
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ABSTRACT:
SUBMITTER: Chaluvally-Raghavan P
PROVIDER: S-EPMC4261159 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Chaluvally-Raghavan Pradeep P Zhang Fan F Pradeep Sunila S Hamilton Mark P MP Zhao Xi X Rupaimoole Rajesha R Moss Tyler T Lu Yiling Y Yu Shuangxing S Pecot Chad V CV Aure Miriam R MR Peuget Sylvain S Rodriguez-Aguayo Cristian C Han Hee-Dong HD Zhang Dong D Venkatanarayan Avinashnarayan A Krohn Marit M Kristensen Vessela N VN Gagea Mihai M Ram Prahlad P Liu Wenbin W Lopez-Berestein Gabriel G Lorenzi Philip L PL Børresen-Dale Anne-Lise AL Chin Koei K Gray Joe J Dusetti Nelson J NJ McGuire Sean E SE Flores Elsa R ER Sood Anil K AK Mills Gordon B GB
Cancer cell 20141201 6
Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated as miR569), which is overexpressed in a subset of ovarian and breast cancers, at least in part due to the 3q26.2 amplicon, alters cell survival and proliferation. Downregulation of TP53INP1 expression ...[more]
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