Ontology highlight
ABSTRACT:
SUBMITTER: Buchovecky CM
PROVIDER: S-EPMC4261228 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Buchovecky Christie M CM Hill Misty G MG Borkey Jennifer M JM Kyle Stephanie M SM Justice Monica J MJ
Current protocols in mouse biology 20130101
Mouse models recapitulate many symptoms of Rett Syndrome, an X-linked disorder caused by mutations in methyl-CpG-binding protein 2 (MECP2). The study of <i>Mecp2</i>-null male mice has provided insight into pathogenesis of the disorder; most recently, dysregulation of cholesterol and lipid metabolism. Perisymptomatic treatment with statin drugs successfully mitigates the effects of this metabolic syndrome, increases longevity and improves motor function. Described here is a metabolic drug screen ...[more]