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Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester).

ABSTRACT: A three-step route was used to synthesize 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester) from 1,4,7,10-tetraazacyclododecane (cyclen). The overall time of reaction was reduced from a combined ~56 h to 2.3 h with an overall yield comparable to previously reported methods.

SUBMITTER: Hopper LE 

PROVIDER: S-EPMC4261951 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Rapid synthesis of 1,7-bis(<i>t</i>-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-<i>t</i>-Bu ester).

Hopper Lauren E LE   Allen Matthew J MJ  

Tetrahedron letters 20141001 40

A three-step route was used to synthesize 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester) from 1,4,7,10-tetraazacyclododecane (cyclen). The overall time of reaction was reduced from a combined ~56 h to 2.3 h with an overall yield comparable to previously reported methods. ...[more]

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