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ABSTRACT:
SUBMITTER: Jagadish B
PROVIDER: S-EPMC3607631 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20121128 23
The synthesis and structure-activity relationships of a homologous series of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid gadolinium(III) complexes bearing thiol-terminated alkyl side chains from three to nine carbons in length are reported. The observed binding with human serum albumin (HSA) of the compounds having C-3 through C-7 side chain lengths was inhibited by homocysteine in a manner consistent with single-site binding. The observed binding with HSA of the compounds having C- ...[more]