Ontology highlight
ABSTRACT:
SUBMITTER: Arunachalam PS
PROVIDER: S-EPMC7303014 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Arunachalam Prabhu S PS Charles Tysheena P TP Joag Vineet V Bollimpelli Venkata S VS Scott Madeleine K D MKD Wimmers Florian F Burton Samantha L SL Labranche Celia C CC Petitdemange Caroline C Gangadhara Sailaja S Styles Tiffany M TM Quarnstrom Clare F CF Walter Korey A KA Ketas Thomas J TJ Legere Traci T Jagadeesh Reddy Pradeep Babu PB Kasturi Sudhir Pai SP Tsai Anthony A Yeung Bertrand Z BZ Gupta Shakti S Tomai Mark M Vasilakos John J Shaw George M GM Kang Chil-Yong CY Moore John P JP Subramaniam Shankar S Khatri Purvesh P Montefiori David D Kozlowski Pamela A PA Derdeyn Cynthia A CA Hunter Eric E Masopust David D Amara Rama R RR Pulendran Bali B
Nature medicine 20200511 6
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous viral vector regimen to elicit nAbs and cellular immunity, including CD8<sup>+</sup> tissue-resident memory T cells. After ten vaginal challenges with autologous virus, protection was observed in both vac ...[more]