Ontology highlight
ABSTRACT:
SUBMITTER: Arunachalam PS
PROVIDER: S-EPMC7303014 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature medicine 20200511 6
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous viral vector regimen to elicit nAbs and cellular immunity, including CD8<sup>+</sup> tissue-resident memory T cells. After ten vaginal challenges with autologous virus, protection was observed in both vac ...[more]