Ontology highlight
ABSTRACT:
SUBMITTER: Karol SE
PROVIDER: S-EPMC4262553 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Karol Seth E SE Coustan-Smith Elaine E Cao Xueyuan X Shurtleff Sheila A SA Raimondi Susana C SC Choi John K JK Ribeiro Raul C RC Dahl Gary V GV Bowman William Paul WP Taub Jeffrey W JW Degar Barbara B Leung Wing W Downing James R JR Pui Ching-Hon CH Rubnitz Jeffrey E JE Campana Dario D Inaba Hiroto H
British journal of haematology 20140828 1
Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia witho ...[more]