Unknown

Dataset Information

0

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia.

ABSTRACT: Cure rates of children and adults with acute myeloid leukaemia (AML) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP1, ASXL1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML, together with distinct genes that were significantly overexpressed in therapy-resistant AML. Defined gene mutations were sufficient to explain primary induction failure in only a minority of cases. Thus, additional genetic or molecular mechanisms must cause primary chemoresistance in paediatric and adult AML.

SUBMITTER: Brown FC 

PROVIDER: S-EPMC5177472 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Cure rates of children and adults with acute myeloid leukaemia (AML) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP1, ASXL1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML, together with distinct genes that were significantly overexpressed in therapy-resist  ...[more]

Similar Datasets

Unknown Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia.
| S-EPMC8410545 | biostudies-literature
Unknown Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy.
| S-EPMC4262553 | biostudies-literature
Unknown Effectiveness of primary anti-Aspergillus prophylaxis during remission induction chemotherapy of acute myeloid leukemia.
| S-EPMC3993271 | biostudies-literature
Unknown Paediatric chronic myeloid leukaemia: Is it really a different disease?
| S-EPMC6702689 | biostudies-literature
Unknown Multiplex Screening for Interacting Compounds in Paediatric Acute Myeloid Leukaemia.
| S-EPMC8468645 | biostudies-literature
Transcriptomics Paediatric Bone marrow Mesenchymal Stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism
2024-11-11 | GSE277382 | GEO
Unknown Complete remission after the first cycle of induction chemotherapy determines the clinical efficacy of relapse-preventive immunotherapy in acute myeloid leukaemia.
| S-EPMC7027927 | biostudies-literature
Unknown Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients.
| S-EPMC7764299 | biostudies-literature
Unknown Identification of Genes Whose Expression Overlaps Age Boundaries and Correlates with Risk Groups in Paediatric and Adult Acute Myeloid Leukaemia.
| S-EPMC7650662 | biostudies-literature
Unknown Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.
| S-EPMC7184728 | biostudies-literature