Ontology highlight
ABSTRACT:
SUBMITTER: Larson N
PROVIDER: S-EPMC4262670 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Larson Nate N Roberts Sarah S Ray Abhijit A Buckway Brandon B Cheney Darwin L DL Ghandehari Hamidreza H
Macromolecular bioscience 20140904 12
HPMA copolymer-RGDfK (HPMA-RGDfK) conjugates bearing either aminohexylgeldanamycin (AHGDM) or docetaxel (DOC) were synthesized and characterized. In vitro stability and binding were evaluated. Cytotoxicity toward ovarian cancer cells was evaluated and the ability of the conjugates to induce cell death was assessed by combination index analysis. Conjugates bearing AHGDM were more stable and exhibited slower drug release than those bearing DOC. Both conjugates demonstrated the ability to bind to a ...[more]