Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC4263223 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cheng Yebin Y Gao Dexiang D Tong Tiejun T
Biostatistics (Oxford, England) 20140623 1
When testing a large number of hypotheses, estimating the proportion of true nulls, denoted by π(0), becomes increasingly important. This quantity has many applications in practice. For instance, a reliable estimate of π(0) can eliminate the conservative bias of the Benjamini-Hochberg procedure on controlling the false discovery rate. It is known that most methods in the literature for estimating π(0) are conservative. Recently, some attempts have been paid to reduce such estimation bias. Nevert ...[more]