Ontology highlight
ABSTRACT:
SUBMITTER: Vaidya AB
PROVIDER: S-EPMC4263321 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Vaidya Akhil B AB Morrisey Joanne M JM Zhang Zhongsheng Z Das Sudipta S Daly Thomas M TM Otto Thomas D TD Spillman Natalie J NJ Wyvratt Matthew M Siegl Peter P Marfurt Jutta J Wirjanata Grennady G Sebayang Boni F BF Price Ric N RN Chatterjee Arnab A Nagle Advait A Stasiak Marcin M Charman Susan A SA Angulo-Barturen Iñigo I Ferrer Santiago S Belén Jiménez-Díaz María M Martínez María Santos MS Gamo Francisco Javier FJ Avery Vicky M VM Ruecker Andrea A Delves Michael M Kirk Kiaran K Berriman Matthew M Kortagere Sandhya S Burrows Jeremy J Fan Erkang E Bergman Lawrence W LW
Nature communications 20141125
The quest for new antimalarial drugs, especially those with novel modes of action, is essential in the face of emerging drug-resistant parasites. Here we describe a new chemical class of molecules, pyrazoleamides, with potent activity against human malaria parasites and showing remarkably rapid parasite clearance in an in vivo model. Investigations involving pyrazoleamide-resistant parasites, whole-genome sequencing and gene transfers reveal that mutations in two proteins, a calcium-dependent pr ...[more]