Ontology highlight
ABSTRACT:
SUBMITTER: Tonhosolo R
PROVIDER: S-EPMC4784480 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Tonhosolo Renata R Gabriel Heloisa B HB Matsumura Miriam Y MY Cabral Fernanda J FJ Yamamoto Márcio M MM D'Alexandri Fábio L FL Sussmann Rodrigo A C RAC Belmonte Rodrigo R Peres Valnice J VJ Crick Dean C DC Wunderlich Gerhard G Kimura Emília A EA Katzin Alejandro M AM
FEBS letters 20101029 23
Herein, we show that intraerythrocytic stages of Plasmodium falciparum have an active pathway for biosynthesis of menaquinone. Kinetic assays confirmed that plasmodial menaquinone acts at least in the electron transport. Similarly to Escherichia coli, we observed increased levels of menaquinone in parasites kept under anaerobic conditions. Additionally, the mycobacterial inhibitor of menaquinone synthesis Ro 48-8071 also suppressed menaquinone biosynthesis and growth of parasites, although off-t ...[more]