Ontology highlight
ABSTRACT:
SUBMITTER: Akey DL
PROVIDER: S-EPMC4263348 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Akey David L DL Brown W Clay WC Dutta Somnath S Konwerski Jamie J Jose Joyce J Jurkiw Thomas J TJ DelProposto James J Ogata Craig M CM Skiniotis Georgios G Kuhn Richard J RJ Smith Janet L JL
Science (New York, N.Y.) 20140206 6173
Flaviviruses, the human pathogens responsible for dengue fever, West Nile fever, tick-borne encephalitis, and yellow fever, are endemic in tropical and temperate parts of the world. The flavivirus nonstructural protein 1 (NS1) functions in genome replication as an intracellular dimer and in immune system evasion as a secreted hexamer. We report crystal structures for full-length, glycosylated NS1 from West Nile and dengue viruses. The NS1 hexamer in crystal structures is similar to a solution he ...[more]