Ontology highlight
ABSTRACT:
SUBMITTER: Turlin E
PROVIDER: S-EPMC4263509 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Turlin Evelyne E Heuck Gesine G Simões Brandão Maria Inês MI Szili Noémie N Mellin J R JR Lange Norbert N Wandersman Cécile C
MicrobiologyOpen 20140926 6
In most organisms, heme biosynthesis is strictly controlled so as to avoid heme and heme precursor accumulation, which is toxic. Escherichia coli regulates heme biosynthesis by a feedback loop involving heme-induced proteolytic cleavage of HemA, glutamyl-tRNA reductase, which is the first enzyme in the heme biosynthetic pathway. We show here that heme homeostasis can be disrupted by overproduction of YfeX, a cytoplasmic protein that captures iron from heme that we named deferrochelatase. We also ...[more]