Ontology highlight
ABSTRACT:
SUBMITTER: Fitzpatrick AWP
PROVIDER: S-EPMC5447821 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature microbiology 20170515
The MacA-MacB-TolC assembly of Escherichia coli is a transmembrane machine that spans the cell envelope and actively extrudes substrates, including macrolide antibiotics and polypeptide virulence factors. These transport processes are energized by the ATPase MacB, a member of the ATP-binding cassette (ABC) superfamily. We present an electron cryo-microscopy structure of the ABC-type tripartite assembly at near-atomic resolution. A hexamer of the periplasmic protein MacA bridges between a TolC tr ...[more]