Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.
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ABSTRACT:
SUBMITTER: Heinrich C
PROVIDER: S-EPMC4264057 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.
Heinrich Christophe C Bergami Matteo M Gascón Sergio S Lepier Alexandra A Viganò Francesca F Dimou Leda L Sutor Bernd B Berninger Benedikt B Götz Magdalena M
Stem cell reports 20141120 6
The adult cerebral cortex lacks the capacity to replace degenerated neurons following traumatic injury. Conversion of nonneuronal cells into induced neurons has been proposed as an innovative strategy toward brain repair. Here, we show that retrovirus-mediated expression of the transcription factors Sox2 and Ascl1, but strikingly also Sox2 alone, can induce the conversion of genetically fate-mapped NG2 glia into induced doublecortin (DCX)(+) neurons in the adult mouse cerebral cortex following s ...[more]
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