Ontology highlight
ABSTRACT:
SUBMITTER: Pereira M
PROVIDER: S-EPMC5599255 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Pereira Maria M Birtele Marcella M Shrigley Shelby S Benitez Julio Aguila JA Hedlund Eva E Parmar Malin M Ottosson Daniella Rylander DR
Stem cell reports 20170824 3
Converting resident glia into functional and subtype-specific neurons in vivo by delivering reprogramming genes directly to the brain provides a step forward toward the possibility of treating brain injuries or diseases. To date, it has been possible to obtain GABAergic and glutamatergic neurons via in vivo conversion, but the precise phenotype of these cells has not yet been analyzed in detail. Here, we show that neurons reprogrammed using Ascl1, Lmx1a, and Nurr1 functionally mature and integra ...[more]