Ontology highlight
ABSTRACT:
SUBMITTER: Barros SA
PROVIDER: S-EPMC4265365 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Barros Stephanie A SA Chenoweth David M DM
Angewandte Chemie (International ed. in English) 20140924 50
The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a new class of structure-specific nucleic acid junction stabilizers based on a triptycene scaffold. Triptycenes provide significant stabilization of DNA and RNA thre ...[more]