Ontology highlight
ABSTRACT:
SUBMITTER: Yang E
PROVIDER: S-EPMC4265747 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yang Emmy E Qian Weiping W Cao Zehong Z Wang Liya L Bozeman Erica N EN Ward Christina C Yang Bin B Selvaraj Periasamy P Lipowska Malgorzata M Wang Y Andrew YA Mao Hui H Yang Lily L
Theranostics 20150101 1
Understanding the effects of immune responses on targeted delivery of nanoparticles is important for clinical translations of new cancer imaging and therapeutic nanoparticles. In this study, we found that repeated administrations of magnetic iron oxide nanoparticles (IONPs) conjugated with mouse or human derived targeting ligands induced high levels of ligand specific antibody responses in normal and tumor bearing mice while injections of unconjugated mouse ligands were weakly immunogenic and in ...[more]